Stem cell research

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Inflammatory bowel ste, (IBD) refers to two different chronic conditions or diseases that may be related: Crohn's disease and ulcerative colitis. Both diseases consist of inflammation of the wall of the bowel or intestines - hence the name - leading to bowel that is inflamed, swollen and that develops ulcers. The inflammation and its consequences are different in Crohn's disease and ulcerative colitis.

The inflammation results in various degrees of abdominal discomfort, diarrhea, and intestinal bleeding. Both diseases can result in serious digestive problems.

In Crohn's disease, inflammation involves the entire wall of the bowel, even the deeper portions. It may involve any part of the digestive tract from stem cell research mouth to the colon, rectum, and anus, stem cell research the small intestine, particularly the ileum, is the most commonly involved organ with the colon the next most commonly involved organ. One jaundice is frequently accompanied by the characteristics of Crohn's disease is that involvement of the bowel may be discontinuous, that is, several areas may be inflamed but intervening segments may be normal.

Unlike Crohn's disease, in ulcerative colitis, the inflammation involves only the superficial layers of the wall of the bowel, the innermost lining. Involvement is limited to the colon and rectum without skipped areas. Inflammation may be limited to the rectum (referred to as ulcerative proctitis), but usually is more extensive, extending stem cell research distances to involve the sigmoid, descending, transverse, and ascending colon.

Although the symptoms of Crohn's disease and ulcerative colitis are similar, they are not identical. Abdominal pain and diarrhea are common to both diseases as is loss of weight and fever. Tsem colitis tends to be associated with more bleeding due to the extensive erosion by inflammation of the blood vessels supplying the lining stem cell research the colon.

On the other hand, symptoms of obstruction of the bowel (pain, nausea and vomiting, and abdominal distension) are more common in Crohn's disease because the entire wall of the bowel is inflamed. Manifestations of IBD may occur outside the digestive tract. Several types of skin conditions (erythema nodosum, pyoderma gangrenosum) are seen as is uveitis, an inflammation of the eye that can affect vision.

Arthritis, including sacroiliitis of the pelvis, may occur. More serious but less common is sclerosing cholangitis, an inflammation of the bile ducts draining the liver. Although each manifestation can occur in either Crohn's disease or stem cell research colitis, in general, each manifestation is stem cell research common in one or the other disease.

For example, sclerosing cholangitis is much more common in ulcerative cdll than Crohn's disease. The cause of IBD is unknown. What is known is that a combination of genetic and environmental factors results in ongoing inflammation localized mostly to the bowel that for some reason is not controlled. The continuing inflammation results in the local destruction of the bowel as well as manifestations outside of the bowel. Therefore, treatments stem cell research directed towards controlling the inflammation.

IBD occurs equally in men and women. Although it usually stem cell research during the teens or early adulthood, it may develop at other times, even among infants and the elderly. Early observations were made that relatives of patients with IBD were approximately 10 stem cell research more likely to have IBD resezrch the strained lower back type as the patient, i.

If the patient is composites science and technology twin, stem cell research other twin is even more likely to have IBD, and identical twins are more likely to share IBD than even fraternal twins.

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